Altered ATP Release and Metabolism in Dorsal Root Ganglia of Neuropathic Rats
نویسندگان
چکیده
منابع مشابه
Altered ATP release and metabolism in dorsal root ganglia of neuropathic rats
BACKGROUND Adenosine 5'-triphosphate (ATP) has a ubiquitous role in metabolism and a major role in pain responses after tissue injury. We investigated the changes in basal and KCl-evoked ATP release from rat dorsal root ganglia (DRG) after peripheral neuropathy induction by unilateral sciatic nerve entrapment (SNE). RESULTS After SNE, rats develop long-lasting decreases in ipsilateral hindpaw...
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It has been generally assumed that the cell body (soma) of a neuron, which contains the nucleus, is mainly responsible for synthesis of macromolecules and has a limited role in cell-to-cell communication. Using sniffer patch recordings, we show here that electrical stimulation of dorsal root ganglion (DRG) neurons elicits robust vesicular ATP release from their somata. The rate of release event...
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Peripheral nerve injury is often followed by the development of severe neuropathic pain. Nerve degeneration accompanied by inflammatory mediators is thought to play a role in generation of neuropathic pain. Neuronal cell death follows axonal degeneration, devastating a vast number of molecules in injured neurons and the neighboring cells. Because we have little understanding of the cellular and...
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ژورنال
عنوان ژورنال: Molecular Pain
سال: 2008
ISSN: 1744-8069,1744-8069
DOI: 10.1186/1744-8069-4-66